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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Alcohol Clin Exp Res. 2021 Jun 2;45(7):1348–1358. doi: 10.1111/acer.14630

Figure 5.

Figure 5.

Electrophysiology: siKcnk13, not siKcnk12, reduced ethanol excitation of rat VTA neurons

A. siKcnk13 was included in the recording pipette. Change in firing rate of VTA neurons produced by ethanol early in the recording and at least 2 hours after initiation of the recording. The response to ethanol was significantly reduced by the inclusion of siKcnk13in the recording pipette. (Two-way RM ANOVA, F1,7=6.58 P<0.05, n=8)

B. siKcnk12 included in the recording pipette. Change in firing rate of VTA neurons produced by ethanol early in the recording and at least 2 hours after initiation of the recording. The response to ethanol was not significantly reduced by the inclusion of siKcnk12 in the recording pipette. (Two-way RM ANOVA, F1,6=0.002 P>0.05, n=7)