Table 2.

Median percentage changes in lipids and glucose after 1 year of statin or niacin-statin therapy in CPC and AIM-HIGH subjects.

Study	Variable	Statin (%)	P Value	Statin + Niacin (%)	P Value	Statin vs. Statin + Niacin P Value
CPC	Triglycerides	−27 (−45; −4)	0.0004	−46 (−59; −24)	<0.0001	0.0015
	LDL-C	−42 (48; −30)	<0.0001	−51 (−60; −41)	<0.0001	0.0016
	HDL-C	10 (0; 20)	0.0001	26 (16; 43)	<0.0001	<0.0001
	Glucose	2 (4; 8)	0.334	6 (−1; 11)	0.0001	0.0887
AIM-HIGH	Triglycerides	−6 (−27; 17)	0.423	−23 (−43; −5)	0.0001	0.0023
	LDL-C	−11 (−22; 13)	0.0784	−10 (−27; 13)	0.106	0.996
	HDL-C	11 (2; 23)	<0.0001	21 (11; 36)	<0.0001	0.0013
	Glucose	6 (−3; 10)	0.00130	9 (2; 14)	<0.0001	0.103

^*Values are median (interquartile range) of percentage changes from baseline. P values for percentage change after 1 year of therapy are from the Wilcoxon matched-pairs signed rank test. P values for the changes between monotherapy and combination therapy are from the Wilcoxon rank-sum test.