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. 2021 Jul 21;12:4445. doi: 10.1038/s41467-021-24767-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Left panel activity of CD137xPD-L1 and CD137xPD-1 bispecifics in a CD137 NFκB-luc reporter assay (fold induction of luciferase signal) Right panel experiment repeated with the addition of an Fc binding antibody; b Left panel levels of IL-2 released by activated T cells after 3 days of incubation with eight candidate CD137xPD-L1 bAb combinations in a dose titration in the presence of CHO-PD-L1 cells, Right panel, experiment repeated in the presence wildtype CHO cells; c levels of IL-2, IFNγ and TNFα released by activated T cells after 3 days of incubation with the three best performing CD137xPD-L1 bAbs and control antibodies in a dose titration in the presence of CHO-PD-L1 cells (bAb001 = MCLA-145).