. 2021 Jul 21;11:14906. doi: 10.1038/s41598-021-94403-1

Table 2.

Rates of positive BRCA1 and BRCA2 mutations; subgroup analysis.

Variable		Total	Positive Mutations
Variable		Total	BRCA1	BRCA2	BRCA1& BRCA2	P-Value*
Age at diagnosis (years)	≤ 35	341	16	34	50 (14.7%)	0.017
Age at diagnosis (years)	> 35	275	9	16	25 (9.1%)	0.017
One or more close relative with breast cancer at any age	Yes	305	9	37	46 (15.1%)	0.029
One or more close relative with breast cancer at any age	No	311	15	14	29 (9.3%)	0.029
One or more close relatives with breast cancer diagnosed at age 50 years or younger	Yes	153	3	24	27 (17.6%)	0.017
	No	463	22	26	48 (10.4%)	0.017
Diagnosed at ≤ 60 years with triple negative disease	Yes	69	16	7	23 (33.3%)	< 0.001
Diagnosed at ≤ 60 years with triple negative disease	No	547	9	43	52 (9.5%)	< 0.001
Any age with at least 2 breast cancer primaries	Yes	48	6	8	14 (29.2%)	< 0.001
Any age with at least 2 breast cancer primaries	No	568	19	42	61 (10.7%)	< 0.001
Two or more close relatives with breast cancer	Yes	97	5	24	29 (30.0%)	< 0.001
Two or more close relatives with breast cancer	No	519	20	26	46 (8.9%)	< 0.001
All patients		616	25	50	75 (12.2%)