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. 2021 Jul 21;11:14825. doi: 10.1038/s41598-021-94214-4

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Discriminative cues produce steady drug-seeking during abstinence. (A) An overview of the protocol to measure drug seeking after abstinence from heroin self-administration using discriminative drug cues. Animals underwent an identical experimental protocol as described in Experiment 1 except with modified light and tone cues. (B, C, E, F) The number of infusions and lever presses during heroin self-administration at a 0.075 mg/kg/infusion dosage (B, C) and a lower 0.03 mg/kg/infusion dosage (E, F). (D, G) Lever pressing during the relapse test after forced abstinence from the 0.075 mg/kg/infusion dosage (D) and the 0.03 mg/kg/infusion dosage (G). Error ± SEM. *p < 0.05.