. 2021 Jul 21;11:14897. doi: 10.1038/s41598-021-94116-5

Table 2.

Participants’ clinical characteristics.

Factors	Control (n = 100)	Unrupture IA (n = 100)	Rupture IA (n = 100)	p value
Age (years)	60 (53–66)	59 (50–67)	55.5 (49.25–62.75)	0.123^a
Men	57 (57%)	53 (53%)	50 (50%)	0.609^b
CRP (mg/L)	2.81 (1.6–7.09)	4 (2.22–8.37)*	8.64 (3–19.47)*^,#	< 0.001^a
TC (mmol/L)	4.42 ± 0.12	4.33 ± 0.11	4.35 ± 0.11	0.851^c
LDL-C (mmol/L)	2.99 ± 0.10	2.68 ± 0.07	2.81 ± 0.10	0.077^c
HDL-C (mmol/L)	1.06 (0.87–1.29)	1.19 (0.88–1.56)*	1.19 (0.96–1.48) *	0.027^a
GLU (mmol/L)	5.36 (4.88–6.66)	4.98 (4.46–5.63)*	6.29 (5.31–7.56)*^,#	< 0.00^a
TG (mmol/L)	1.27 (0.91–1.83)	1.46 (0.91–1.75)	1.08 (0.76–1.48)*^,#	0.021^a
UA (mmol/L)	356 (255–405.75)	304 (232–369.75)*	242 (163.75–323)*^,#	< 0.001^a
HbA1c (mmol/L)	6.1 (5.6–7.5)	6 (5.6–6.67)	5.7 (5.5–6)*^,#	< 0.001^a
Creatinine (μmol/L)	70 (58–81.75)	65 (57–79)*	60 (50–71)*^,#	< 0.001^a
Hcy (mmol/L)	8.2 (9.85–13.8)	8.05 (6.25–10.17)*	9.32 (7.8–13.07)^#	< 0.001^a
BNP (pg/mL)	91.14 (45.08–180.11)	77.09 (42.01–113.09)*	180 (61.48–578.95)*^,#	< 0.001^a
Hypertension	42 (42%)	40 (40%)	44 (44%)	0.849^b
Diabetes mellitus	14 (14%)	19 (19%)	14 (14%)	0.532^b
Coronary heart disease	7 (7%)	11 (11%)	8 (8%)	0.578^b
cerebral infarction	15 (15%)	14 (14%)	18 (18%)	0.720^b
Hypertension + Diabetes mellitus	18 (18%)	11 (11%)	13 (13%)	0.340^b
Others	4 (4%)	5 (5%)	3 (3%)	0.769^b
Smoking status				0.697^b
Never	30 (30%)	23 (23%)	28 (28%)
Current	26 (26%)	33 (33%)	29 (29%)
Previously	21 (21%)	25 (25%)	27 (27%)
Occasionally	23 (23%)	19 (19%)	16 (16%)
Alcohol drinking				0.528^b
Never	22 (22%)	28 (28%)	25 (25%)
≤ 3 times/week	33 (33%)	34 (34%)	34 (34%)
> 4 times/week	15 (15%)	17 (17%)	22 (22%)
Occasionally	30 (30%)	21 (21%)	19 (19%)
Hunt Hess Grade	0 (0–0)	0 (0–0)*	2 (1–3)*^,#	< 0.001^a
GCS Grade	0 (0–0)	15 (15–15)*	15 (14–15)*^,#	< 0.001^a
WFNS Grade	0 (0–0)	1 (1–1)*	1 (1–2)*^,#	< 0.001^a
mRS	0 (0–0)	0 (0–0)*	0 (0–2)*^,#	< 0.001^a