Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 21;7:95. doi: 10.1038/s41523-021-00305-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a Primary tumour volume in Placebo (P) (day 2: n = 11 tumours (n = 8 mice), day 5: n = 11 tumours (n = 7 mice), day 12: n = 13 tumours (n = 7 mice)), Anakinra (A) (day 2: n = 9 tumours (n = 7 mice), day 5: n = 9 tumours (n = 6 mice), day 12: n = 13 tumours (n = 8 mice), Dox and Zol (DZ) (day 2: n = 8 tumours (n = 6 mice), day 5: n = 15 tumours (n = 8 mice), day 12: n = 15 tumours (n = 8 mice)), Anakinra, Dox, and Zol (ADZ) (day 2: n = 8 tumours (n = 5 mice), day 5: n = 13 tumours (n = 8 mice), day 12: n = 13 tumours (n = 7 mice)). Data are mean +/− SEM, two-way ANOVA with Tukey’s multiple comparisons test (A vs. P *P = 0.01, A vs. DZ **P = 0.002, A vs. ADZ ***P = 0.0001). b, c PCNA⁺ and Cleaved-Caspase 3⁺ cells (%) in primary tumours. Each data point represents one or more tissue sections from an individual primary tumour. Data are mean +/− SD. One-way ANOVA with Tukey’s multiple comparisons test (P vs. ADZ *P = 0.04, A vs. ADZ *P = 0.02). Scale bar = 50 µm. d Casp3⁺ IHC. e, f Metastases (%) and BLI images (P (n = 7 mice), A (n = 8 mice), DZ (n = 8 mice), or ADZ (n = 7 mice)). Fisher’s exact test: *P = 0.02 P vs. ADZ (bone metastases); *P = 0.04 DZ vs. ADZ (lung metastases). g, h Animals with metastases (%) (P (n = 6), A (n = 6), DZ (n = 6), or ADZ (n = 6)) (intra-cardiac injection of E0771 luc2 GFP cells). i, j Animals with metastases (%) P (n = 8), A (n = 8), DZ (n = 8), or ADZ (n = 7) (intra-cardiac injection of 4T1 luc2 cells). k–m BV/TV % in tibiae from the spontaneous metastasis (k) and overt bone metastasis (L-C57BL/6, M-BALB/c) models.