Table 1.
Baseline characteristics, BMD and hormone levels.
| Acute ADT (n = 7) | Chronic ADT (n = 30) | Former ADT users (n = 21) | PCa Controls (n = 30) | p value | |
|---|---|---|---|---|---|
| Age | 71.6 (63.22–77.75) | 71.15 (67.98–73.97) | 74.50 (70.50–77.23) | 69.70 (68.45–72.45) | 0.243 |
| Weight | 91.1 (81.81–104.45.0) | 87.20 (83.48–96.76) | 79.50 (77.38–90.84) | 85.25 (80.42–91.50) | 0.313 |
| Height | 169 (167.54–174.89) | 175.25 (171.07–176.78) | 175.20 (170.71–176.63) | 176.50 (173.38–178.80) | 0.157 |
| BMI | 32.50 (28.31–35.17) | 29.30 (27.91–31.48) | 28.00 (25.96–29.73) | 27.65 (26.06–29.36) | 0.085 |
| BMD | |||||
| Lumbar spine (g/cm2) | 1.194 (1.158–1.314) | 1.165 (1.093–1.247) | 1.312 (1.184–1.410) | 1.307 (1.229–1.375) | 0.094 |
| Femoral neck (g/cm2) | 0.949 (0.745–1.083) | 0.864 (0.836–0.939) | 0.858 (0.826–0.973) | 0.946 (0.905–0.990) | 0.242 |
| One-third distal radius (g/cm2) | 0.975 (0.806–1.061) | 0.918 (0.882–0.960) | 0.950 (0.913–1.003) | 0.990 (0.944–1.028) | 0.098 |
| Ultradistal forearm (g/cm2) | 0.471 (0.411–0.526) | 0.446 (0.415–0.465) | 0.477 (0.442–0.508) | 0.483 (0.445–0.509) | 0.17 |
| Total body (g/cm2) | 1.171 (1.052–1.346) | 1.096 (1.072–1.184) | 1.188 (1.134–1.239) | 1.214 (1.166–1.262) | 0.032 |
| Hormones | |||||
| Testosterone (ng/mL) | 0.048 (− 0.769 to 2.049) | 0.063 (0.047–0.167) | 3.780 (2.448–5.087) | 4.335 (3.802–4.870) | < 0.0001 |
| Estradiol (pg/mL) | 5.0 (− 20.31 to 67.39) | 5.00 (4.39–7.56) | 24.40 (16.53–28.99) | 23.24 (20.92–26.60) | < 0.0001 |
| Parathyroid hormone (pg/mL) | 39.14 (31.08–56.48) | 42.93 (36.56–48.47) | 41.20 (37.25–48.98) | 39.91 (37.98–49.38) | 0.995 |
| 25-Hydroxyvitamin D (ng/mL) | 24.10 (18.43–32.15) | 29.91 (26.41–35.39) | 29.99 (25.64–35.85) | 32.55 (29.00–36.49) | 0.305 |
Results for continuous variables are presented as median (95% CI). Testosterone: 1 ng/mL = 3.47 nmol/L; Estradiol: 1 pg/mL = 3.671 pmol/L; Parathyroid hormone: 1 pg/mL = 0.106 pmol/L; 25-hydroxyvitamin D: 1 ng/mL = 2.496 nmol/L.