Table 2.
Baseline serum levels of bone markers.
| Baseline | Acute ADT (n = 7) | Chronic ADT (n = 30) | Former ADT users (n = 21) | PCa Controls (n = 30) | p value |
|---|---|---|---|---|---|
| DKK-1 (pg/mL) | 1288.09 (881.57–1980.65) | 1161.04 (1143.91–1442.62) | 1332.65 (1186.30–1498.84) | 1237.03 (1147.87–1437.50) | 0.683 |
| Sclerostin (pg/mL) | 3099.91 (1814.84–5849.45) | 2971.95 (2596.11–3274.92) | 2309.84 (2138.82–3093.34) | 2621.55 (2196.47–2688.09) | 0.029 |
| OPG (pg/mL) | 350.23 (159.91–730.62) | 404.56 (384.99–475.76) | 426.51 (373.30–527.94) | 329.90 (306.14–429.88) | 0.032 |
| 6 months | Acute ADT (n = 6) | Chronic ADT (n = 24) | Former ADT users (n = 16) | PCa Controls (n = 26) | |
|---|---|---|---|---|---|
| DKK-1 (pg/mL) | 1072.35 (741.22–1717.95) | 1004.37 (996.29–1285.94) | 1216.66 (1118.74–1364.56) | 1011.25 (942.17–1136.37) | 0.077 |
| Sclerostin (pg/mL) | 2267.46 (483.37–6441.37) | 2942.04 (2784.74–3499) | 2606.02 (2359.12–3335.16) | 2328.44 (2155.13–2778.16) | 0.045 |
| OPG (pg/mL) | 350.22 (136.03–687.46) | 402.20 (367.14–479.43) | 373.43 (345.60–522.62) | 290.49 (257.98–380.31) | 0.006 |
Results are presented as median (95% CI). DKK1 Dickkopf-1, OPG osteoprotegerin.