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. 2021 Jul 21;12(8):722. doi: 10.1038/s41419-021-04013-y

Fig. 4. Knockdown PPM1G inhibited tumor growth of HCC cells in vivo.

Fig. 4

A PPM1G is required for tumor growth of Hep3B cells in nude mice. Hep3B cells with PPM1G knockdown or transfected with vector were injected into the nude mice (n = 5). Tumor sizes were examined after every two days after 22 days of transplantation. B Validate the expression of PPM1G in tumors. The expression of PPM1G in three pairs of transplanted tumors was examined. GAPDH was used as an internal control. C Decreased tumor size in HCC with PPM1G knockdown. Mice were sacrificed after 32 days of transplantation and the image of tumors was shown. D Decreased tumor weight in HCC with PPM1G knockdown. The tumor weight of each tumor was examined after 32 days of transplantation.