Table 2.
Survival of MM patients.
| Median Survival, m (95% CI) | PFS | P value | OS | P value | |
|---|---|---|---|---|---|
| Gender | Male | 29.6 (19.5–39.7) | 0.116 | / | / |
| Female | 42.9 (32.7–53.2) | / | / | ||
| Age | ≤68 years | 41.8 (34.6–49.0) | 0.005 | 63.1(52.9–73.4) | 0.005 |
| >68 years | 21.2 (15.7–26.7) | 44.0 (35.0–52.9) | |||
| Type of M protein | non-IgD | 38.1 (29.8–46.4) | <0.001 | 63.0 (57.3–68.6) | 0.014 |
| IgD | 16.3 (12.3–20.3) | 38.2 (19.0–57.4) | |||
| D-S | 1 + 2+3A | 38.7 (31.7–45.7) | 0.019 | 63.1(52.7–73.5) | <0.001 |
| 3B | 18.6 (14.2–23.0) | 33.4 (19.7–47.0) | |||
| ISS | 1 + 2 | 41.8 (34.1–49.5) | 0.048 | 64.0 (52.2–75.8) | <0.001 |
| 3 | 21.8 (11.7–31.9) | 42.6 (34.2–50.9) | |||
| RISS | 1 + 2 | 38.1 (30.4–45.8) | 0.002 | 64.8 | <0.001 |
| 3 | 18.9 (16.3–21.5) | 36.2 (28.6–43.7) | |||
| Hgb | ≥100 g/L | 38.7 (30.6–46.8) | 0.203 | 64.8 | 0.018 |
| <100 g/L | 28.4 (18.1–38.8) | 56.8 (43.8–69.7) | |||
| Plt | ≥150 × 109/L | 42.8 (32.2–53.4) | 0.001 | 63.0 | 0.001 |
| <150 × 109/L | 24.1 (15.4–32.8) | 49.0 (40.1–57.9) | |||
| Bone marrow plasma cells percentage | ≤30% | 45.4 (34.9–55.8) | <0.001 | NR | <0.001 |
| > 30% | 23.6 (17.5–29.7) | 51.1 (39.0–63.3) | |||
| Cr | ≤177 umol/L | 38.1 (30.6–45.6) | 0.077 | 63.1 (52.8–73.5) | <0.001 |
| >177 umol/L | 20.7 (16.7–24.6) | 38.2 (23.4–52.9) | |||
| LDH | ≤245 u/L | 42.8 (35.1–50.5) | <0.001 | 64.0 (52.3–75.6) | <0.001 |
| >245 u/L | 18.8 (14.0–23.7) | 32.0 (21.3–42.8) | |||
| CRP | ≤8 g/L | 34.6 (24.6–44.5) | 0.122 | 63.0 (53.3–72.6) | 0.020 |
| >8 g/L | 23.5 (16.3–30.7) | 44.0 (33.6–54.3) | |||
| Spleen | Normal | 43.1 (34.6–51.5) | <0.001 | 64.8 | <0.001 |
| Enlarged | 18.6 (15.1–22.1) | 32.0 (29.8–34.3) | |||
| EMM | <0.001 | <0.001 | |||
| Without | 38.1 (30.6–45.6) | 61.4 (55.9–67.0) | |||
| Single EMM | 34.6 (5.2–63.9) | 64.8 (23.9–105.7) | |||
| >1 EMM | 10.4 (6.1–14.6) | 25.0 (8.9–41.1) | |||
| EMM | <0.001 | <0.001 | |||
| Without | 38.1 (30.6–45.6) | 61.4 (55.9–67.0) | |||
| EMB | 23.5 (2.8–44.2) | 64.8 (34.3–95.3) | |||
| EME | 5.9 (2.6–9.1) | 14.9 (4.6–25.2) | |||
| EMM | <0.001 | <0.001 | |||
| Without | 38.1 (30.6–45.6) | 61.4 (55.9–67.0) | |||
| Single EMB | 34.6 (5.4–63.7) | 64.8 (24.0–105.6) | |||
| >1 EME or EMB | 11.2 (7.6–14.8) | 30.8 (21.6–40.0) | |||
| >1 EMB with EME | 8.3 (3.6–13.0) | 17.6 (9.6–25.7) |
CI, confidence interval; PFS, Progression-free survival; OS, Overall survival; D-S, Durie-Salmon Staging; ISS, International Staging System; R-ISS, Revised International Staging System; Hgb, hemoglobin; Plt, platelet; Cr, creatinine; LDH, lactate dehydrogenase; CRP, C-reaction protein; EMM, extramedullary multiple myeloma; EMB, extramedullary-bone related; EME, extramedullary extraosseous.