Table 3.
PFS of MM patients.
| Univariable analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|
| Variable | HR (95% CI) | P value | Variable | HR (95% CI) | P value |
| Gender Female | 0.79 (0.59–1.06) | 0.116 | Age > 68years | 1.59 (1.13–2.25) | 0.008 |
| Age > 68 years | 1.57 (1.14–2.16) | 0.005 | Type of M protein IgD | 2.69 (1.52–4.77) | 0.001 |
| Type of M protein IgD | 2.67 (1.66–4.30) | <0.001 | RISS 3 vs 1 + 2 | 1.53 (1.08–2.16) | 0.017 |
| D-S 3B vs 1 + 2+3A | 1.54 (1.07–2.22) | 0.019 | Bone marrow plasma cells percentage >30% | 1.73 (1.25–2.41) | 0.001 |
| ISS 3 vs 1 + 2 | 1.35 (1.00–1.82) | 0.048 | Spleen enlarged | 1.67 (1.18–2.36) | 0.004 |
| RISS 3 vs 1 + 2 | 1.68 (1.20–2.34) | 0.002 | EMM | ||
| Hgb <100 g/L | 1.21 (0.90–1.64) | 0.203 | Single EMB vs non-EM | 1.24 (0.80–1.92) | 0.338 |
| Plt <150 × 109/L | 1.61 (1.20–2.16) | 0.001 | >1 EME or EMB vs non-EM | 2.73 (1.46–5.13) | 0.002 |
| Bone marrow plasma cells percentage >30% | 1.77 (1.32–2.37) | <0.001 | >1 EME and EMB vs non-EM | 12.48 (5.15–30.23) | <0.001 |
| Cr >177umol/L | 1.38 (0.96–1.99) | 0.077 | |||
| LDH >245 u/L | 2.08 (1.49–2.92) | <0.001 | |||
| CRP >8 g/L | 1.30 (0.93–1.81) | 0.122 | |||
| Spleen enlarged | 2.15 (1.56–2.96) | <0.001 | |||
| EMM | |||||
| Single EMM vs non-EM | 1.13 (0.76–1.70) | 0.545 | |||
| >1 EMM vs non-EM | 2.99 (1.85–4.85) | <0.001 | |||
| EMM | |||||
| EMB vs non-EM | 1.30 (0.91–1.85) | 0.152 | |||
| EME vs non-EM | 8.54 (4.12–17.73) | <0.001 | |||
| EMM | |||||
| Single EMB vs non-EM | 1.10 (0.72–1.66) | 0.668 | |||
| >1 EME or EMB vs non-EM | 2.40 (1.36–4.25) | 0.003 | |||
| >1 EME and EMB vs non-EM | 7.68 (3.54–16.66) | <0.001 | |||
PFS, Progression-free survival; HR, hazard ratio; CI, confidence interval; D-S, Durie-Salmon Staging; ISS, International Staging System; R-ISS, Revised International Staging System; Hgb, hemoglobin; Plt, platelet; Cr, creatinine; LDH, lactate dehydrogenase; CRP, C-reaction protein; EMM, extramedullary multiple myeloma; EM, Extramedullary lesions; EMB, extramedullary-bone related; EME, extramedullary extraosseous.