Table 4.
OS of MM patients.
| Univariable analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|
| Variable | HR (95% CI) | P value | Variable | HR (95% CI) | P value |
| Gender Female | 0.84 (0.59–1.20) | 0.343 | Age >68 years | 1.64 (1.07–2.49) | 0.022 |
| Age >68 years | 1.88 (1.29–2.72) | 0.001 | D-S 3B vs 1 + 2+3A | 1.93 (1.13–3.28) | 0.016 |
| Type of M protein IgD | 2.09 (1.15–3.80) | 0.014 | RISS 3 vs 1 + 2 | 1.76 (1.11–2.79) | 0.017 |
| D-S 3B vs 1 + 2+3A | 2.61 (1.76–3.87) | <0.001 | Bone marrow plasma cell percentage>30% | 1.68 (1.11–2.55) | 0.015 |
| ISS 3 vs 1 + 2 | 2.19 (1.54–3.10) | <0.001 | Spleen enlarged | 1.91 (1.26–2.91) | 0.003 |
| RISS 3 vs 1 + 2 | 2.74 (1.88–4.01) | <0.001 | EMM | ||
| Hgb <100 g/L | 1.55 (1.07–2.26) | 0.020 | Single EMB vs non-EM | 1.35 (0.75–2.43) | 0.316 |
| Plt <150 × 109/L | 1.79 (1.27–2.54) | 0.001 | >1 EME or EMB vs non-EM | 3.16 (1.55–6.44) | 0.002 |
| Bone marrow plasma cell percentage >30% | 2.05 (1.45–2.92) | <0.001 | >1 EME and EMB vs non-EM | 6.88 (2.96–16.02) | <0.001 |
| Cr >177 umol/L | 2.45 (1.66–3.62) | <0.001 | |||
| LDH >245 u/L | 2.54 (1.75–3.69) | <0.001 | |||
| CRP >8 g/L | 1.56 (1.07–2.28) | 0.020 | |||
| Spleen enlarged | 2.63 (1.83–3.79) | <0.001 | |||
| EMM | |||||
| Single EMM vs non-EM | 0.98 (0.58–1.67) | 0.940 | |||
| >1 EMM vs non-EM | 3.43 (2.03–5.81) | <0.001 | |||
| EMM | |||||
| EMB vs non-EM | 1.19 (0.76–1.86) | 0.450 | |||
| EME vs non-EM | 8.74 (4.30–17.78) | <0.001 | |||
| EMM | |||||
| Single EMB vs non-EM | 0.92 (0.54–1.59) | 0.775 | |||
| >1 EME or EMB vs non-EM | 2.52 (1.31–4.86) | 0.006 | |||
| >1 EME or EMB vs non-EM | 8.21 (3.90–17.32) | <0.001 | |||
OS, Overall survival; HR, hazard ratio; CI, confidence interval; D-S, Durie Salmon Staging; ISS, International Staging System; R-ISS, Revised International Staging System; Hgb, hemoglobin; Plt, platelet; Cr, creatinine; LDH, lactate dehydrogenase; CRP, C-reaction protein; EMM, extramedullary multiple myeloma; EM, Extramedullary lesions; EMB, extramedullary-bone related; EME, extramedullary extraosseous.