Table 2.
Hazard ratios and 95% confidence intervals (CIs) for the associations between douching and genital talc use at ages 10–13 and cervical cancers diagnosed prior to enrollment [n = 49,302 (Participants with complete confounder information)].
| Person-time at risk (years)a | Non-cases; N(%) N = 48,779b |
Cervical cancer cases, N(%) N = 523b |
Age-adjusted hazard ratio (95% CI) |
Adjusted hazard ratioc (95% CI) |
Fully adjusted hazard ratioc,d (95% CI) |
|
|---|---|---|---|---|---|---|
| Douching, ages 10–13 | ||||||
| Ever use | ||||||
| No | 2,003,222 | 46,552 (97) | 496 (96) | 1.00 | 1.00 | 1.00 |
| Yes | 60,934 | 1525 (3) | 22 (4) | 1.40 (0.91, 2.14) | 1.45 (0.94, 2.22) | 1.32 (0.86, 2.03) |
| Frequency of use | ||||||
| None | 2,003,222 | 46,552 (97) | 496 (96) | 1.00 | 1.00 | 1.00 |
| Sometimes | 55,036 | 1378 (3) | 19 (4) | 1.34 (0.84, 2.11) | 1.38 (0.87, 2.18) | 1.26 (0.80, 2.00) |
| Frequently | 5898 | 147 (0) | 3 (1) | 1.99 (0.64, 6.24) | 2.16 (0.68, 6.82) | 1.88 (0.59, 5.95) |
| p-trend = 0.10 | p-trend = 0.07 | p-trend = 0.16 | ||||
| Genital talc use, ages 10–13 | ||||||
| Ever use | ||||||
| No | 1,580,656 | 36,905 (80) | 399 (81) | 1.00 | 1.00 | 1.00 |
| Yes | 393,069 | 9,131 (20) | 96 (19) | 0.97 (0.77, 1.21) | 0.97 (0.77, 1.21) | 0.95 (0.76, 1.19) |
| Frequency of use | ||||||
| None | 1,580,656 | 36,905 (80) | 399 (81) | 1.00 | 1.00 | 1.00 |
| Sometimes | 332,832 | 7,751 (17) | 81 (16) | 0.96 (0.76, 1.22) | 0.96 (0.75, 1.22) | 0.94 (0.74, 1.20) |
| Frequently | 60,237 | 1,380 (3) | 15 (3) | 1.00 (0.59, 1.67) | 1.00 (0.59, 1.69) | 0.98 (0.58, 1.66) |
| p-trend = 0.82 | p-trend = 0.81 | p-trend = 0.71 | ||||
| Combined ever use, ages 10–13 | ||||||
| Neither | 1,543,967 | 36,006 (79) | 389 (79) | 1.00 | 1.00 | 1.00 |
| Both | 27,891 | 688 (2) | 8 (2) | 1.10 (0.55, 2.22) | 1.15 (0.57, 2.31) | 1.04 (0.52, 2.10) |
| Talc/no douching | 356,534 | 8,238 (18) | 87 (18) | 0.97 (0.77, 1.23) | 0.97 (0.76, 1.22) | 0.95 (0.75, 1.21) |
| Douching/no talc | 21,739 | 552 (1) | 9 (2) | 1.56 (0.81, 3.03) | 1.62 (0.83, 3.16) | 1.41 (0.72, 2.75) |
Missing: douching (n = 702 non-cases, 5 cases), genital talc use (n = 2,743 non-cases, 28 cases), both (n = 3,295 non-cases, 30 cases).
aParticipants with complete confounder information.
bWith age as the primary time scale, adjusting for weight relative to peers at age 10 (ordinal), race/ethnicity (non-Hispanic White, non-Hispanic Black/African-American, Hispanic/Latina, or other), childhood socioeconomic status (well off, middle income, low income, poor), and age at menarche (< 12, 12–13 ≥ 14).
cAdditionally adjusted for in utero diethylstilbestrol exposure (yes or no), regular drinking before age 14 (yes/no), and smoking before age 14 (yes/no).