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. 2021 Jul 21;12:4434. doi: 10.1038/s41467-021-24684-7

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© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A high-fat diet (HFD) meal leads to increase in Abca1 expression and lysosomal function in Tim4⁺ resident adipose tissue macrophages (ATMs). CD36 mediates lipoprotein particle uptake by ATMs, and Tim4 is required for lysosomal activation following uptake. Blocking Tim4 prevents lysosomal activation in ATMs and inhibits post-prandial HDLc release.