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. 2021 Jan 22;26(6):2429–2439. doi: 10.1038/s41380-020-00984-0

Fig. 2. Comparison of SNP-based heritability (h2) estimates and impact of population prevalence.

Fig. 2

SNP-h2 was computed with linkage disequilibrium score regression (LDSC) on the liability scale for a range of population prevalence (K) values for severe major depressive episode (mddnarrow and mddbroad PREFECT case definitions) and for a large sample of more moderate cases (mdd2019, Psychiatric Genomics Consortium—Major Depressive Disorder Working Group sample excluding 23andMe). Pointwise 95% confidence intervals shaded.