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. 2021 Jul 21;11(8):378. doi: 10.1007/s13205-021-02911-8

Table 3.

List of microalgae derived products and co-products

Sl. no. Products Co-products Strain Yield Productivity Applications/advantages References
1 Biofuel Biodiesel

Chlorella pyrenoidosa

Botryococcus sp.

95.1%

88%

1.44 g/g/h

0.22 g/g/h

Biodiesel is better than diesel fuel in terms of sulphur content, flash point, aromatic content, and bio-degradability

Biodiesel is an environmentally friendly alternative liquid fuel that can be used in any diesel engine without modification

Job creation for the local population, provision of modern energy carriers to rural communities

Cheng et al. (2016a, b);

Sivaramakrishnan and Incharoensakdi (2017)

Bioethanol

Chlamydomonas sp. KNM0029C

Scenedesmus raciborskii WZKMT

0.22 g/g biomass

79.38 g/L

0.22 g/g/day

0.66 g/L/h

Biomethanol as a renewable fuel. Bioethanol fuel reduces lead, sulphur, CO, and particulate emissions

20% blending of bioethanol with gasoline is acceptable

Kim et al. (2020a, b);

Alam et al. (2019)

Biohydrogen

Chlamydomonas reinhardtii

Rhodopseudomonas sphaeroides

Botryococcus braunii

Chlorella vulgaris/ Spirulina

40% v/v

45% v/v

64% v/v

70–75% v/v

Cleanest biofuel, only water as by-product

High energy content as compared to gasoline

Hemschemeier et al. (2008)
2 Lipids Eicosapentaenoic acid (EPA)

Cocculinella minutissima

Monodus subterraneus

Phaeodactylum tricornutum

36.7 mg/L

96.3 mg/L 43.4 mg/L

EPA is most commonly used for heart disease, preventing adverse events after a heart attack, de-pression, and menopause McKinlay et al. (2010)
Docosahexaenoic acid (DHA)

B. carterae

Crypthecodinium cohnii

Nannochloropsis oculata

8.6 mg/L

19.5 mg/L

2.6 mg/L

Reduce inflammation and your risk of chronic diseases, such as heart disease

DHA supports brain function and eye health

3 Pigments Lutein

Haematococcus pluvialis

Chlorella sorokiniana MB-1

7.15 mg/g dry weight

5.21 mg/g

10.83 mg/g/h

5.78 mg/L/day

Lutein is another promising candidate in cosmetics, pharmaceuticals, and nutraceutical formulations. It can filter blue light (high-energy photons) from the visible light spectrum and can scavenge free radicals generated from biochemical reactions after lipid peroxidation

Molino et al. (2018);

Chen et al. (2016)

β-carotene

Dunaliella salina

Nannochloropsis gaditana

32 mg/L

100.1

4.57 mg/L/day

β-carotene can stimulate the immune system, supplement for diseases including cancer, coronary heart diseases, premature ageing, and arthritis

β-carotene prevents cataracts, night blindness, and skin diseases

Used as food colourants to improve the appearance of margarine, cheese, fruit juices, baked goods, dairy products

Prevention of oxidation of low density protein that can be applied to prevent arteriosclerosis, coronary heart disease, and ischemic brain development

Xi et al. (2020)
Astaxanthin Haematococcus pluvialis 18.5 mg/g dry weight 13.9 mg/g/h

Dietary administration of astaxanthin has proven to inhibit carcinogenesis in the mouse urinary bladder, rat oral cavity, and rat colon

Astaxanthin has the ability to induce xenobiotic metabolising enzymes in rat liver

Antioxidant property

Protection against excessive sunlight

Used in the respiratory mechanism of protoplasm

Molino et al. (2018)
Xanthophyll

Scenedesmu almeriensis

Synechococcus sp.

Chlorella vulgaris

Nannochloropsis gaditana

20.0 mg/L

1510 mg/L

80 mg/L

25 mg/L

Macias-Sanchez et al. (2005); Macias-Sanchez et al. (2010)
Chlorophyll Spirulina platensis 0.9 mg/L

Chlorophyll is an essential compound not only used as an additive in pharmaceutical but also used in cosmetic product

Chlorophyll a has been extensively used as a colouring agent because of its stability

Chlorophyll compounds usually have medicinal application because of their wound-healing and anti-inflammatory properties

Chauhan and Pathak (2010)
4 Proteins Phycobiliproteins Anabaena NCCU-9 124.9 mg/g

Phycobiliproteins are used in fluorescent labelling, flow cytometry, fluorescent microscopy, and fluorescent immunohistochemistry

Used as natural dye in food and cosmectics, with phycocyanin in particular used as a blue pigment used in products such as chewing gum, popsicles, confectionary, soft drinks, dairy products, and wasabi, as well as cosmetic products, such as lipstick and eyeliner

Nutraceutical applications such as anti-oxidative, anti-inflammatory, anti-viral, anti-tumour, neuroprotective, and hepatoprotective activities

Used as animal feed

Hemlata and Fatma, (2009); Silveira et al. (2007); Chaneva et al. (2007)
Phycocyanin

Spirulina platensis

Arthronema africanum

0.0036 mg/L

0.23 mg/L

0.0009 mg/L/h
5 Vitamins Thiamine Tetraselmis suecica 493–750 mg

Used as food supplements

Used as drug supplements to treat diseases including malnutrition

Safafar et al. (2015)
Riboflavin Dunaliella tertiolecta 31.2 mg
a-tocopherol Chlorella stigmatophora 669 µg/g