Table 2.
The characteristics of ARDS in children with hematologic neoplasms: survivors and non-survivors.
| Characteristic | Survivor (n = 20) | Non-survivor (n = 25) | P-value |
|---|---|---|---|
| Sex (male/female) | 13/7 | 13/12 | 0.380 |
| Age (n %) | 0.415 | ||
| <6 month | 2 (10.0%) | 0 (0%) | |
| <2 year | 3 (15.0%) | 7 (28.0%) | |
| 2–6 year | 10 (50.0%) | 12 (48.0%) | |
| 7–17 year | 5 (25.0%) | 6 (24.0%) | |
| Agranulocytosis (n %) | 8 (40.0%) | 10 (40.0%) | 1.000 |
| CRP ( s, mg/L) | 86.2 ± 63.2 | 112.8 ± 65.4 | 0.175 |
| PCT (n, ng/mL) | 1.2 (0.4, 3.3) | 2.2 (1.1, 14.2) | 0.138 |
| VIS (n %) | 0.037 | ||
| <50 | 17 (85.0%) | 14 (56.0%) | |
| 50–100 | 3 (15.0%) | 5 (20.0%) | |
| >100 | 0 (0%) | 6 (24.0%) | |
| VIS (n) | 2.5 (0, 17.3) | 30 (10, 97.5) | 0.002 |
| Fluid balance in the first 3 days (ml/kg/d) | −2.7 (−12.4, 5.4) | 4.5 (−3.4, 10.3) | 0.019 |
| Fluid balance in the first 7 days (ml/kg/d) | −1.1 (−9.7, 3.9) | 3.9 (−3.9, 13.8) | 0.029 |
| Total length of mechanical ventilation [( s), d] | 17.4 ± 12.6 | 8.2 ± 5.7 | 0.007 |
| PEEP [( s), cmH2O] | 9.9 ± 2.7 | 10.5 ± 3.2 | 0.818 |
| PIP [( s), cmH2O] | 27.6 ± 5.3 | 29.8 ± 4.9 | 0.147 |
| OI( s) | 16.2 ± 7.4 | 19.5 ± 12.0 | 0.404 |
| CRRT therapy (n %) | 0.045 | ||
| Yes | 1 (5.0%) | 7 (28.0%) | |
| No | 19 (95.0%) | 18 (72.0%) | |
| Total hospital stay [( s), d] | 41.2 ± 19.7 | 18.6 ± 13.2 | 0.042 |
| Total length of PICU [( s), d] | 21.6 ± 12.8 | 8.2 ± 5.6 | 0.000 |
| Type of primary blood tumors [n (%)] | 0.835 | ||
| Acute lymphocytic leukemia | 9 (45.0%) | 12 (48.0%) | |
| Acute myeloid leukemia | 9 (45.0%) | 8 (32.0%) | |
| Biclonal leukemia | 0 (0%) | 1 (4.0%) | |
| Others* | 2 (10.0%) | 4 (16.0%) | |
| MODS [n (%)] | 0.013 | ||
| With MODS | 7 (35.0%) | 18 (72.0%) | |
| Without MODS | 13 (65.0%) | 7 (28.0%) | |
| PCIS score( s) | 79.1 ± 5.3 | 66.6 ± 8.3 | 0.000 |
| Severity of ARDS [n (%)] | 0.637 | ||
| Mild | 1 (5.0%) | 0 (0%) | |
| Moderate | 11 (55.0%) | 16 (64.0%) | |
| Severe | 8 (40.0%) | 9 (36.0%) |
CRP, C Reactive Protein; PCT, Procalcitonin; VIS, vasoactive inotropic score; PEEP, Positive end-expiratory pressure; PIP, Peak Inspiratory Pressure; OI, Oxygenation index; CRRT, continuous renal replacement therapy; MODS, multiple organ dysfunction syndrome; PCIS, pediatric critical illness scoring; ARDS, acute respiratory distress syndrome.
*
Others included biclonal leukemia (n = 1), myelodysplastic syndrome (n = 2), Hodgkin lymphoma (n = 1), and non-Hodgkin's lymphoma (n = 3).