Table 5.
IC50 values for CDPK7 binding to MHC class I molecules obtained using the IEDBa.
MHC-II alleleb | Start-stopc | Peptide sequence | Percentile rankd | Antigenicity |
---|---|---|---|---|
CDPK7 | CDPK7 | |||
H2-Db | 1882-1891 | SSPSSLPTPI | 0.15 | 0.4079 |
143-152 | SNLPNLDRYM | 0.21 | -0.4284 | |
1637-1646 | SQLLSTVYYL∗ | 0.24 | 0.9146 | |
| ||||
H2-Dd | 647-656 | KGPTKSAMLL∗ | 0.18 | 0.9201 |
1612-1621 | VRGGELFDLI | 0.28 | 0.1770 | |
1483-1492 | VGGRQYGFAI | 0.64 | 0.1561 | |
| ||||
H2-Kb | 1721-1730 | IMYLLLRGRL∗ | 0.55 | 1.4751 |
798-807 | SSASFSSRGM∗ | 1.0 | 1.3623 | |
1643-1652 | VYYLHKCGIV | 1.2 | 0.1373 | |
| ||||
H2-Kd | 1474-1483 | CYVELLSEQV∗ | 0.79 | 0.5079 |
1445-1454 | RYYVLVDNML∗ | 1.15 | 0.9079 | |
822-831 | GYSASGGMIV∗ | 1.3 | 0.9579 | |
| ||||
H2-Kk | 1555-1564 | TNELYAIKVI | 0.12 | 0.2695 |
1084-1093 | SEGPATTPSI | 0.75 | 0.2366 | |
694-703 | DVEGIVDKII | 1.5 | 0.1511 | |
| ||||
H2-Ld | 1589-1598 | HPNVIYMKEL | 3.8 | 0.2773 |
1729-1738 | RLPFPINQAF | 4.2 | 0.3317 | |
279-288 | YEPHPLLARL | 4.6 | 0.1027 |
aThe immune epitope database (http://tools.iedb.org/mhci/). bH2-Db, H2-Dd, H2-Kb, H2-Kd, H2-Kk, and H2-Ld alleles are mouse MHC class I molecules. cTen amino acids for analysis were used each time. dLow percentile rank = high level binding; high percentile rank = low level binding; IC50 values = percentile rank. ∗ indicates potential antigenic epitopes (threshold = 0.5).