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. 2021 May 7;118(18):320–325. doi: 10.3238/arztebl.m2021.0022

Table 1. Spread of malignant lymphomas according to the Ann Arbor staging system.

Stage Involvement Extranodal (E) status
I Involvement of the lymph nodes in one lymph node region A single localized, extralymphatic manifestation without lymph node involvement
II Involvement of two or more lymph node regions on the same side of the diaphragm Localized involvement of an extranodal organ or extranodal localization and one or several lymph node regions on the same side of the diaphragm
III Involvement of lymph node regions on both sides of the diaphragm Localized involvement of extralymphatic organs accompanied by lymph node involvement on both sides of the diaphragm
IV Diffuse extralymphatic involvement; liver involvement is always considered as diffuse involvement Not applicable