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. 2021 May 7;118(18):320–325. doi: 10.3238/arztebl.m2021.0022

eTable. Recommendation grades and confidence in the evidence by endpoint according to GRADE.

Strength of recommendation Description Expression
A Strong recommendation Should/must
B Recommendation Should
0 Recommendation not definite/open to interpretation Can
Confidence in the evidence Description Symbol
High confidence We are very certain that the true effect is close to the estimated effect. graphic file with name Dtsch_Arztebl_Int-118_0320_002.jpg graphic file with name Dtsch_Arztebl_Int-118_0320_002.jpg graphic file with name Dtsch_Arztebl_Int-118_0320_002.jpg graphic file with name Dtsch_Arztebl_Int-118_0320_002.jpg
Moderate confidence We have moderate confidence in the effect estimate: the true effect is probably close to the estimate, but there is a possibility that it differs to a relevant degree. graphic file with name Dtsch_Arztebl_Int-118_0320_002.jpg graphic file with name Dtsch_Arztebl_Int-118_0320_002.jpg graphic file with name Dtsch_Arztebl_Int-118_0320_002.jpg graphic file with name Dtsch_Arztebl_Int-118_0320_003.jpg
Low confidence Our confidence in the effect estimate is limited: the true effect may well be different from the estimate to a relevant degree. graphic file with name Dtsch_Arztebl_Int-118_0320_002.jpg graphic file with name Dtsch_Arztebl_Int-118_0320_002.jpg graphic file with name Dtsch_Arztebl_Int-118_0320_003.jpg graphic file with name Dtsch_Arztebl_Int-118_0320_003.jpg
Very low confidence We have very little confidence in the effect estimate: the true effect probably differs from the estimated effect to a relevant degree. graphic file with name Dtsch_Arztebl_Int-118_0320_002.jpg graphic file with name Dtsch_Arztebl_Int-118_0320_003.jpg graphic file with name Dtsch_Arztebl_Int-118_0320_003.jpg graphic file with name Dtsch_Arztebl_Int-118_0320_003.jpg

GRADE, Guidelines Recommendation Assessment Development