eTable. Recommendation grades and confidence in the evidence by endpoint according to GRADE.
Strength of recommendation | Description | Expression | |||
A | Strong recommendation | Should/must | |||
B | Recommendation | Should | |||
0 | Recommendation not definite/open to interpretation | Can | |||
Confidence in the evidence | Description | Symbol | |||
High confidence | We are very certain that the true effect is close to the estimated effect. | ![]() |
![]() |
![]() |
![]() |
Moderate confidence | We have moderate confidence in the effect estimate: the true effect is probably close to the estimate, but there is a possibility that it differs to a relevant degree. | ![]() |
![]() |
![]() |
![]() |
Low confidence | Our confidence in the effect estimate is limited: the true effect may well be different from the estimate to a relevant degree. | ![]() |
![]() |
![]() |
![]() |
Very low confidence | We have very little confidence in the effect estimate: the true effect probably differs from the estimated effect to a relevant degree. | ![]() |
![]() |
![]() |
![]() |
GRADE, Guidelines Recommendation Assessment Development