表1. 4192例初诊急性髓系白血病患者融合基因的分布情况.
| 融合基因 | 例数(%) | 性别(例) |
年龄[例(%)] |
|||
| 男性(2304例) | 女性(1888例) | 0~14岁(292例) | >14岁(3900例) | P值 | ||
| PML-RARα | 795(18.96) | 418 | 377 | 70(23.97) | 725(18.60) | 0.023 |
| RUNX1-RUNX1T1 | 628(14.98) | 385 | 243 | 76(26.03) | 552(14.15) | <0.001 |
| CBFβ-MYH11 | 229(5.46) | 140 | 89 | 18(6.16) | 211(5.41) | 0.584 |
| MLL-AF9 | 66(1.57) | 31 | 35 | 11(3.77) | 55(1.41) | 0.004 |
| MLL-AF6 | 37(0.88) | 16 | 21 | 4(1.37) | 33(0.85) | 0.549 |
| BCR-ABL | 19(0.45) | 12 | 7 | 1(0.34) | 18(0.46) | 0.873 |
| MLL-ELL | 31(0.74) | 16 | 15 | 1(0.34) | 30(0.77) | 0.641 |
| DEK-CAN | 25(0.60) | 12 | 13 | 2(0.68) | 23(0.59) | 0.849 |
| MLL-AF10 | 30(0.72) | 12 | 18 | 11(3.77) | 19(0.49) | <0.001 |
| NUP98-HOXA9 | 18(0.43) | 10 | 8 | 0(0) | 18(0.46) | 1.000 |
| TLS-ERG | 18(0.43) | 9 | 9 | 1(0.34) | 17(0.44) | 0.819 |
| MLL-ENL | 10(0.24) | 5 | 5 | 1(0.34) | 9(0.23) | 0.515 |
| SET-CAN | 7(0.17) | 6 | 1 | 2(0.68) | 5(0.13) | 0.080 |
| MLL-AF1q | 5(0.12) | 0 | 5 | 3(1.03) | 2(0.05) | 0.003 |
| AML1-MDS1/EVI1 | 4(0.10) | 4 | 0 | 0(0) | 4(0.10) | 1.000 |
| AML1-MTG16 | 4(0.10) | 3 | 1 | 1(0.34) | 3(0.08) | 0.251 |
| STAT5b-RARα | 3(0.07) | 2 | 1 | 0(0) | 3(0.08) | 1.000 |
| MLL-AF17 | 3(0.07) | 2 | 1 | 0(0) | 3(0.08) | 1.000 |
| MLL-AF4 | 2(0.05) | 1 | 1 | 0(0) | 2(0.05) | 1.000 |
| NUP98-HOXD13 | 2(0.05) | 2 | 0 | 0(0) | 2(0.05) | 1.000 |
| PLZF-RARα | 2(0.05) | 1 | 1 | 0(0) | 2(0.05) | 1.000 |
| NUP98-PMX1 | 1(0.02) | 1 | 0 | 0(0) | 1(0.03) | 1.000 |
| NPM-MLF1 | 1(0.02) | 1 | 0 | 0(0) | 1(0.03) | 1.000 |
| NUP98-HOXA13 | 1(0.02) | 0 | 1 | 0(0) | 1(0.03) | 1.000 |
| NUP98-HOXA11 | 1(0.02) | 0 | 1 | 0(0) | 1(0.03) | 1.000 |
| CBFβ-MYH11和BCR-ABL | 3(0.07) | 2 | 1 | 0(0) | 3(0.08) | 1.000 |
| PML-RARα和BCR-ABL | 1(0.02) | 1 | 0 | 0(0) | 1(0.03) | 1.000 |
| DEK-CAN和SET-CAN | 1(0.02) | 1 | 0 | 0(0) | 1(0.03) | 1.000 |
| TEL-ABL和MLL-ELL | 1(0.02) | 0 | 1 | 0(0) | 1(0.03) | 1.000 |