TABLE 6.
Multivariable frailty model displaying the hazard ratio (HR) and 95% confidence interval (CI) (time to all causes of withdrawal)
| Variable (baseline) | Comparison | HR | 95% CI | P |
|---|---|---|---|---|
| Treatment | S+BNZ vs BNZ | 0.74 | 0.61‐0.89 | .001 |
| Heart rate (bpm) | >140 vs ≤140 | 1.40 | 1.15‐1.70 | .001 |
| LA : Ao | >2.2 vs ≤2.2 | 1.45 | 1.17‐1.79 | .001 |
| LVIDDn | >2.1 vs ≤2.1 | 1.61 | 1.31‐1.98 | <.001 |
| Furosemide (mg/kg) | >4.12 vs ≤4.12 | 1.54 | 1.26‐1.89 | <.001 |
| VHS | >11.9 vs ≤11.9 | 1.23 | 1.01‐1.50 | .04 |
| Chloride (mEq/L) | >110 vs ≤110 | 0.79 | 0.64‐0.96 | .02 |
| Systolic blood pressure (mm Hg) | >131 vs ≤131 | 0.82 | 0.68‐0.99 | .05 |
Notes: Mean site variance of the study site, 0.10 (SE, 0.05, P = .02).
Abbreviations: BNZ, benazepril group; BUN, blood urea nitrogen; LA : Ao, left atrium to aortic root diameter ratio; LVIDDn, normalized left ventricular dimension at end‐diastole; S+BNZ, spironolactone and benazepril group; VHS, vertebral heart size.