. 2021 Jun 2;35(4):1789–1799. doi: 10.1111/jvim.16163

TABLE 1.

Characteristics of healthy dogs, dogs with acute kidney injury due to other causes (AKI‐nL), dogs with leptospirosis without and with leptospiral pulmonary hemorrhage syndrome (LPHS)

Variable	Reference range	Healthy		AKI‐nL		Leptospirosis without LPHS		Leptospirosis with LPHS
Variable	Reference range	n	Median (IQR)	n	Median (IQR)	n	Median (IQR)	n	Median (IQR)
Age (y)		20	7.4 (5.3‐9.0)	34	4.5 (1.0‐9.0)	15	5.0 (1.0‐8.0)	16	6.0 (2.3‐8.8)
Body weight (kg)		31	24.8 (21.0‐28.0)	34	27.2 (20.5‐32.1)	15	25.0 (17.5‐30.6)	17	26.0 (12.9‐33.0)
Sex		31		34		15		17
Male (n; intact/neutered)			6/11		5/13		4/2		8/5
Female (n; intact/ neutered)			3/11		3/13		2/7		0/4
Hematocrit (L/L)	0.39‐0.57	10	0.47 (0.45‐0.51)	34	0.39 (0.32‐0.43) ^a	14	0.38 (0.34‐0.44) ^c	17	0.30 (0.26‐0.35) ^a ^, ^b ^, ^d
Thrombocytes (10³/μL)	150‐400	11	336 (279‐434)	33	209 (132‐311) ^a	14	161 (35‐315) ^a	17	138 (88‐208) ^a
Leucocyte count (10³/μL)	6‐12	10	6.6 (6.0‐8.7)	33	12.5 (8.0‐19.5)	14	14.0 (10.9‐19.6)	17	13.7 (9.6‐15.8)
Mature neutrophils (10³/μL)	3‐11.5	11	4.6 (3.7‐5.0)	33	11.0 (6.6‐15.9) ^a	14	11.1(8.4‐15.8) ^a	17	10.7 (7.9‐13.1) ^a
Band neutrophils (10³/μL)	0‐0.3	10	0.06 (0‐0.13)	33	0.11 (0‐0.57)	14	0.14 (0.07‐0.54)	17	0.14 (0‐0.4)
Urea (mg/dL)	19.8‐64.7	11	34.2 (32.4‐54.7)	34	300.3 (200.6‐372.4) ^a	15	309.3 (120.1‐368.2) ^a	17	343.5 (255.3‐409.0) ^a
Creatinine (mg/dL)	0.6‐1.3	11	0.8 (0.7‐0.9)	34	8.0 (5.2‐12.7) ^a	15	7.4 (3.5‐10.2) ^a	17	9.7 (8.0‐13.6) ^a
Bilirubin (mg/dL)	0.03‐0.23	11	0.02 (0.01‐0.04)	32	0.20 (0.15‐0.33) ^a	15	0.22 (0.16‐0.44) ^a	17	0.21 (0.17‐2.23) ^a
Albumin (g/dL)	3.0‐4.1	11	3.36 (3.07‐3.52)	34	2.85 (2.2‐3.14) ^a	15	2.75 (2.58‐3.04) ^a	17	2.31 (2.05‐2.65) ^a
CRP (mg/L)	0‐10.7	11	1.1 (0‐6.2) ^c ^, ^d	29	14.1 (2.6‐50.2) ^c ^, ^d	8	44.5 (38.5‐141.3) ^a ^, ^b	11	53.1 (32.0‐89.8) ^a ^, ^b
Outcome
Alive to discharge n (%)		—	—	25	25 (73.5)	14	14 (93.3)	13	13 (76.5)
Euthanized/died n (%)		—	—	9	9 (26.5)	1	1 (6.7)	4	4 (23.5)

Note: Data are shown as medians and interquartile ranges unless stated otherwise. Significance was defined as P ≤ .05 after Bonferroni correction.

Abbreviations: CRP, C‐reactive protein; IQR, interquartile range; n, number of samples.

^{^a}

Significant difference compared to healthy.

^{^b}

Significant difference compared to AKI due to other causes.

^{^c}

Significant difference compared to leptospirosis with LPHS.

^{^d}

Significant difference compared to leptospirosis without LPHS.