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. 2021 Jul 8;12:667704. doi: 10.3389/fphar.2021.667704

FIGURE 1.

FIGURE 1

Multiple sequence alignment of SARS-CoV-2 (PDB ID: 5R81), SARS-CoV (PDB ID: 2GZ9) and MERS-CoV (PDB ID: 5C3N) main proteases. Binding site residues are marked with blue box. Red marked residues indicate the change observed between SARS-CoV-2 and SARS CoV. * denotes the conserved regions with identical residues. Serine to Alanine change at the 45th position observed in the binding site is marked with circle.