Table 2.
Age- and Sex-Adjusted Linear Regressions of Biomarkers and Each Continuous Clinical Variable in the PAHB (n = 66)
| Variable | ST2 | NT-proBNP |
|---|---|---|
| RAP, mm Hg (n = 65) | 0.05 (–1 to 1.1, .9) | 0.37 (–0.2 to 0.9, .2) |
| mPAP, mm Hg (n = 66) | 5.63 (-0.1 to 11, .05) | 2.99 (–0.03 to 6, .05) |
| PCWP, mm Hg (n = 65) | –0.5 (–1.4 to 0.3, .3) | –0.09 (–0.6 to 0.3, .7) |
| PVR, Wood units (n = 61) | 3.65 (0.9- 6.39, .01)a | 1.46 (–0.01 to 2.95, .05) |
| PVRi, Wood units • m2 (n = 61) | 3.23 (0.07 to 6.39, .04)a | 1.27 (–0.4 to 2.98, .14) |
| Cardiac output, L/min (n = 63) | –0.2 (–0.8 to 0.38, .5) | –0.12 (–0.4 to 0.19, .5) |
| Cardiac index, L/min • m2 (n = 63) | –0.45 (–0.96 to 0.05, .07) | –0.04 (–0.32 to 0.23, .8) |
| 6MWD, m (n = 37) | –161.9 (–306 to –17.2, .03)a | –66 (–121 to –11, .02)a |
| 6MWD % predicted, % (n = 37) | –26 (–48 to –4.4, .02)a | –10 (–18 to –2, .017)a |
| NYHA FC (n = 61) | 1.6 (0.85 to 2.5, < .001)a | 0.7 (0.3 to 1.1, < .001)a |
Each regression coefficient represents a separate model (nine total) of ST2 or NT-proBNP effect (independent variable) on the hemodynamic or functional outcome, with adjustment for age and sex. Data are expressed as regression coefficient (95% CI, P value). The PAHB was limited to subjects with biomarkers obtained within 12 months of clinical tests. The total number of subjects analyzed after accounting for missing values is presented with variable. 6MWD = 6-min walk distance; mPAP = mean pulmonary arterial pressure; NT-proBNP = N-terminal prohormone B-natriuretic peptide; NYHA FC = New York Heart Association functional class; PAHB = National Biological Sample and Data Repository for PAH; PCWP = pulmonary capillary wedge pressure; PVR = pulmonary vascular resistance; PVRi = pulmonary vascular resistance index; RAP = right atrial pressure; ST2 = soluble suppressor of tumorigenicity.
P < 0.05.