Table 3.
Age- and Sex-Adjusted (Mixed Model Longitudinal) Linear Regressions of Biomarkers and Continuous Clinical Variables in Children’s Hospital Colorado Over Time
| Variable | ST2 | NT-proBNP |
|---|---|---|
| RAP, mm Hg | 0.98 (0.34 to 1.6, .003)a | 0.75 (0.46 to 1.0, < .001)a |
| mPAP, mm Hg | 8.4 (5.1 to 11.7, < .001)a | 2.96 (1.2 to 4.7, .001)a |
| PCWP, mm Hg | 0.087 (–0.51 to 0.69, .8) | 0.38 (0.09 to 0.68, .01)a |
| PVR, Wood units | 5.54 (3.6 to 7.5, < .001)a | 2.85 (1.9 to 3.8, < .001)a |
| PVRi, Wood units • m2 | 3.78 (2.4 to 5.2, < .001)a | 2.1 (1.4, 2.8, < .001)a |
| Cardiac output, L/min | –0.19 (–0.45 to 0.07, .9) | –0.24 (–0.37 to –0.11, < .001)a |
| 6MWD, m | –40.9 (–72.6 to –9.1, .01)a | –15.69 (–32.4 to 1.0, .065) |
| 6MWD % predicted, % | –7% (–11.5 to 1.5, .01)a | –1.9% (–4.5 to 0.7, .16) |
| NYHA FC | 0.43 (0.24 to 0.62, < .001)a | 0.22 (0.12 to 0.31, < .001)a |
Each regression coefficient represents a separate model (eight total) of ST2 or NT-proBNP effect (independent variable) on the hemodynamic or functional outcome, with adjustment for age and sex.
Data are expressed as regression coefficient (95% CI, P value). Note that data are reported for change in outcome per 1 natural log unit increase in biomarker. Inverse relationship with the outcome is implied for 1 natural log unit decrease in biomarker. Children’s Hospital Colorado biomarker and clinical tests all concurrent, n = 61, 151 samples. 6MWD = 6-min walk distance; mPAP = mean pulmonary arterial pressure; NT-proBNP = N-terminal prohormone B-natriuretic peptide; NYHA FC = New York Heart Association Functional Class; PCWP = pulmonary capillary wedge pressure; PVR = pulmonary vascular resistance; PVRi = pulmonary vascular resistance index; RAP = right atrial pressure; ST2 = soluble suppressor of tumorigenicity.
P < .05.