Table 4.
Cox Multivariable Hazards Ratios for Clinical Worsening in the PAHB
| Association of Single Covariates | Hazard Ratio (95% CI, P Value) |
|---|---|
| Sex (female, n = 181) | 0.23 (0.06-0.85, .02) |
| Age (y; n = 181) | 1.02 (0.92-1.12, .7) |
| PAH type (n = 181) | 0.94 (0.8-1.2, .7) |
| NYHA FC (n = 132) | 1.68 (0.75-3.7, .2) |
| 6MWD (m; n = 82) | 0.99 (0.98-0.99, .03) |
| SBP (mm Hg; n = 165) | 0.99 (0.97-1.02, .8) |
| Heart rate (beats/min; n = 158) | 0.98 (0.95-1.01, .25) |
| RAP (mm Hg, n = 178) | 1.03 (0.97-1.08, .3) |
| mPAP (mm Hg; n = 181) | 1.05 (1.02-1.08, .002) |
| PVR (Woods unit; n = 168) | 1.03 (0.99-1.06, .17) |
| PVRi (Woods unit • m2; n = 165) | 1.05 (1.0-1.1, .04) |
| Cardiac index (L/min/m2; n = 176) | 1.1 (0.87-1.4, .4) |
| REVEAL score (n = 181) | 1.62 (1.2-2.18, .001) |
| REVEAL risk category (n = 181) | 1.88 (1.2-2.8, .003) |
| ST2 models (hazard ratio per log change in ST2; n = 181) | |
| ST2 Unadjusted | 2.4 (1.5-3.9, < .001) |
| ST2 adjusted for age and sex | 2.85 (1.5-5.1, < .001) |
| ST2 adjusted for age, sex, and PAH type | 2.9 (1.6-5.4, .001) |
| NT-proBNP models (hazard ratio per log change in NT-proBNP; n = 181) | |
| NT-proBNP unadjusted | 1.96 (1.43-2.67, < .001) |
| NT-proBNP adjusted for age and sex | 1.9 (1.4-2.6, < .001) |
| NT-proBNP adjusted for age, sex, and PAH type | 1.91 (1.4-2.6, < .001) |
Biomarkers natural log-transformed. 6MWD = 6-min walk distance; mPAP = mean pulmonary arterial pressure; NT-proBNP = N-terminal prohormone B-natriuretic peptide; NYHA FC = New York Heart Association Functional Class; PAH = pulmonary arterial hypertension; PAHB = National Biological Sample and Data Repository for PAH; PVR = pulmonary vascular resistance; PVRi = pulmonary vascular resistance index; RAP = right atrial pressure; REVEAL = Registry to Evaluate Early and Long-Term PAH Disease Management; SBP = systolic BP; ST2 = soluble suppressor of tumorigenicity.