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. 2021 Jul 20;16:26331055211033847. doi: 10.1177/26331055211033847

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — TBG specifically reduces motivation to seek heroin. (A) TBG (30 mg/kg, IP) or vehicle (VEH) was administered to male Wistar rats 30 minutes prior to a progressive ratio test of motivation to seek food or heroin (separate tests). TBG selectively reduced break points for heroin, but not food (planned comparison, 2-tailed t-test, *P < .05). Motivation to seek heroin is typically much greater than motivation to seek food. However, after administration of TBG, motivation to seek heroin and food were comparable. (B) Using male Wistar rats, we replicated the long-lasting effect of TBG on cued relapse for heroin (42.5 mg/kg cumulative dose, IP). This effect was specific to heroin relapse, and not food relapse (same test). Only VEH-treated rats relapsed at higher rates for heroin than for food (2-way RM ANOVA, Sidak’s post-hoc, *P < .05, ⁺⁺⁺P < .001).