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. 2021 Jul 20;12:20406223211033103. doi: 10.1177/20406223211033103

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© The Author(s), 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Timeline of important studies in the pathogenesis, diagnosis, treatment, and prognostication of ACC over the past 20 years.

ACC, adrenocortical carcinoma; ADIUVO, Efficacy of Adjuvant Mitotane Treatment; EDP, etoposide, doxorubicin, and cisplatin; ENS@T, European Network for the Study of Adrenal Tumors; EURINE-ACT, Evaluation of Urine Steroid Metabolomics in the Differential Diagnosis of Adrenocortical Tumours; FFPE, formalin-fixed paraffin-embedded; FIRM-ACT, First International Randomized Trial in Locally Advanced and Metastatic ACC Treatment; GALACCTIC, A Study of OSI-906 in Patients with Locally Advanced or Metastatic Adrenocortical Carcinoma; JAVELIN, Avelumab in Metastatic or Locally Advanced Solid Tumors; OS, overall survival; PFS, progression-free survival; TCGA-ACC, The Cancer Genome Atlas ACC Study.