Table 2.
Results of subgroup analysis of cricRNAs reported by 16 studies in diagnostic meta-analysis.
| Analysis | No. of studies | Sensitivity (95% CI) | Specificity (95% CI) | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) | AUC(95%CI) | I²(%) | p-value |
|---|---|---|---|---|---|---|---|---|---|
| Overall | 16 | 0.74(0.69-0.79) | 0.79(0.73-0.84) | 3.50(2.78-4.45) | 0.33(0.27-0.39) | 10.74(7.81-14.77) | 0.83(0.79-0.86) | 43.0 | 0.035 |
| Sample type | |||||||||
| tissue | 12 | 0.72(0.7-0.76) | 0.78(0.71-0.84) | 3.26(2.50-4.24) | 0.36(0.32-0.42) | 9.00(6.61-12.25) | 0.80(0.76-0.83) | 0.0 | 0.450 |
| serum or plasma or saliva | 4 | 0.83(0.71-0.91) | 0.83(0.74-0.90) | 4.93(3.32-7.33) | 0.20(0.12-0.34) | 24.70(14.37-42.44) | 0.90(0.87-0.92) | 47.6 | 0.125 |
| Sample size | |||||||||
| ≥100 | 7 | 0.75(0.66-0.82) | 0.83(0.77-0.87) | 4.36(3.33-5.70) | 0.31(0.23-0.41) | 14.22(9.41-24.50) | 0.86(0.83-0.89) | 53.4 | 0.045 |
| <100 | 9 | 0.73(0.66-0.80) | 0.73(0.64-0.81) | 2.76(2.06-3.71) | 0.36(0.30-0.45) | 7.58(5.17-11.11) | 0.79(0.76-0.83) | 0.0 | 0.545 |
| Expression | |||||||||
| downregulated | 11 | 0.71(0.65-0.76) | 0.75(0.67-0.82) | 2.88(2.20-3.76) | 0.38(0.33-0.45) | 7.49(5.38-10.44) | 0.78(0.74-0.82) | 0.0 | 0.797 |
| upregulated | 5 | 0.80(0.68-0.88) | 0.84(0.78-0.89) | 4.94(3.75-6.50) | 0.24(0.16-0.38) | 20.35(13.10-31.62) | 0.89(0.86-0.91) | 18.4 | 0.298 |