Skip to main content
. 2021 Jul 8;8:658029. doi: 10.3389/fmolb.2021.658029

FIGURE 5.

FIGURE 5

Comparison of the glycan binding sites. (A) The superimposition of LNFP1 that bound to P[4]/P[6]/P[8]/P[19] VP8*s. (B) Superimposition of type 1 HBGAs (H1, LNB, LNFP1) that located at the same glycan binding site of P[8] VP8*. (C) The interactions between P[8]/P[19] VP8* and mucin core 2. (D) The potential lewis b binding site in P[8] VP8* based on NMR. (E–G) Surface presentation of the three distinct glycan binding sites in RVA VP8*s. The residues constitute the glycan binding site were labeled. P[14] (cyan, 4DRV), human P[11] (salmon, 4YG0), P[8] (yellow, 6K2O) VP8*s are presented as models. (H) The presentation of the glycan binding site of human group C RV (RVC) VP8* (magenta, PDB ID: 5ZHO). Type A trisaccharide was shown as stick. The residues involved in the glycan binding site are labeled.