Table 3.
Unadjusted and adjusted linear regression models of male anogenital distance according to the maternal use of paracetamol in pregnancy. p-value ≤ 0.05 is considered statistically significant.
| Measures of Male Newborns (n = 277) | Maternal Use of Paracetamol | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Any Trimester | First Trimester | Second Trimester | Third Trimester | ||||||||||
| Mean Value (SD) (mm) | n (Exposed, Not Exposed) | Parameter Estimate a | p-Value | n (Exposed, Not Exposed) | Parameter Estimate a | p-Value | n (Exposed, Not Exposed) | Parameter Estimate a | p-Value | n (Exposed, Not Exposed) | Parameter Estimate a | p-Value | |
| CRUDE MODEL b | |||||||||||||
| AGDAS | 23.3 (4.9) | 171, 106 | 0.1 (−0.23, 0.25) | 0.94 | 102, 175 | 0.12 (−0.12, 0.36) | 0.34 | 112, 165 | 0.08 (−0.16, 0.32) | 0.51 | 96, 181 | 0.19 (−0.05, 0.44) | 0.13 |
| AGDAP | 45.4 (5.4) | 171, 106 | 0.04 (−0.21, 0.28) | 0.76 | 102, 175 | 0.26 (0.01, 0.5) | 0.04 | 112, 165 | −0.1 (−0.34, 0.14) | 0.42 | 96, 181 | 0.05 (−0.2, 0.3) | 0.68 |
| ADJUSTED MODEL c | |||||||||||||
| AGDAS | 23.3 (4.9) | 171, 106 | −0.003 (−0.23, 0.24) | 0.98 | 102, 175 | 0.09 (−0.15, 0.33) | 0.46 | 112, 165 | 0.09 (−0.14, 0.33) | 0.42 | 96, 181 | 0.2 (−0.04, 0.44) | 0.1 |
| AGDAP | 45.4 (5.4) | 171, 106 | 0.03 (−0.2, 0.26) | 0.81 | 102, 175 | 0.22 (−0.01, 0.45) | 0.07 | 112, 165 | −0.08 (−0.31, 0.15) | 0.49 | 96, 181 | 0.06 (−0.17, 0.3) | 0.6 |
AGDAS: anogenital distance from the anus to the posterior base of the scrotum; AGDAP: anogenital distance from the anus to the cephalad insertion of the penis. a Parameter estimate = beta (95%CI). b Unadjusted lineal regression models. AGDs were transformed into Z-scores. c Lineal regression models adjusted by previous pre-term deliveries and gestational age. AGDs were transformed into Z-scores.