Table 4.
Male anogenital distance according to the days of maternal use of paracetamol at any time of the pregnancy and during the first trimester (Mean (SD)). p-value ≤ 0.05 is considered statistically significant.
| Male Newborns (n = 277) | Days of Maternal Use of Paracetamol at Any Time of Pregnancy | ||||||
| Never (n = 105) | 1–3 Days (n = 70) | 4–7 Days (n = 46) | 1–2 Weeks (n = 28) | More Than 2 Weeks (n = 26) | p-Value a | p-Value b | |
| AGDAS (mm) | 23.3 (5.3) | 23.0 (4.7) | 23.2 (4.5) | 23.9 (4.3) | 23.7 (5.3) | 0.93 | 0.86 |
| AGDAP (mm) | 45.3 (5.3) | 45.3 (5.8) | 45.1 (5.3) | 46.1 (5.1) | 45.9 (5.6) | 0.92 | 0.79 |
| Days of Maternal Use of Paracetamol in The First Trimester | |||||||
| Never (n = 176) | 1–3 Days (n = 58) | 4–7 Days (n = 24) | 1–2 Weeks (n = 8) | More than 2 Weeks (n = 11) | p-Value a | p-Value b | |
| AGDAS (mm) | 23.1 (5.1) | 23.5 (4.5) | 24.1 (3.8) | 23.4 (5.9) | 23.6 (5.4) | 0.89 | 0.91 |
| AGDAP (mm) | 44.9 (5.5) | 46.7 (5.1) | 44.9 (5.2) | 48.0 (5.6) | 46.2 (5.1) | 0.12 | 0.13 |
AGDAS: anogenital distance from the anus to the posterior base of the scrotum; AGDAP: anogenital distance from the anus to the cephalad insertion of the penis. aANOVA test. AGDs were transformed into Z-scores. bANCOVA test. AGDs were transformed into Z-scores. Models adjusted by previous pre-term deliveries and gestational age.