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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Epilepsy Res. 2021 May 27;175:106677. doi: 10.1016/j.eplepsyres.2021.106677

Figure 4.

Figure 4.

In vitro, functional activity of lorcaserin, DOI, and 5-HT at human (h) and mouse (m) 5-HT2ARs (A and B) and 5-HT2CRs (C and D). All compounds were tested in parallel measuring inositol phosphate production. Data are concentration–response curves showing means and SEMs from a minimum of three, independent experiments. Eleven concentrations of lorcaserin, in half log-increments, were tested in triplicates, and six concentrations of 5-HT and DOI (controls), in log increments, were tested in duplicates. NC is an abbreviation for “no compound,” and the associated data points represent basal receptor activity.