. 2021 Jul 22;20:69. doi: 10.1186/s12938-021-00900-9

Table 2.

Effect of model changes reflecting different pathological mechanisms (columns) on phenotypic mechanical markers (rows). WT = wall thickness, FA = fractional anisotropy, and Comb. = combination

Metrics	Time period	WT $↑$	Passive force $↑$	Active force $↓$	FA $↑$	Comb.
Wall thickening	Systolic (ES)	$↑$ ( $\approx$ )	$↓$ ( $↓$ )	$↓$ ( $↓$ )	$\approx$ ( $\approx$ )	$↓$ ( $↓$ )
Wall thickening	Diastolic (ED)	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )
Strain (L)	Systolic (ES)	$↑$ ( $↑$ )	$↑$ ( $↑$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$↓$ ( $↓$ )
Strain (L)	Diastolic (ED)	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )
Strain (C)	Systolic (ES)	$↑$ ( $\approx$ )	$↑$ ( $↑$ )	$↑$ ( $↑$ )	$↑$ ( $\approx$ )	$↑$ ( $↑$ )
Strain (C)	Diastolic (ED)	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )
Strain (R)	Systolic (ES)	$↑$ ( $\approx$ )	$↓$ ( $↓$ )	$↓$ ( $↓$ )	$↓$ ( $\approx$ )	$↓$ ( $↓$ )
Strain (R)	Diastolic (ED)	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )
Strain rate (L)	Systolic (ES)	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )
Strain rate (L)	Diastolic (ED)	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$\approx$ ( $\approx$ )	$↓$ ( $\approx$ )
Strain rate (C)	Systolic (ES)	$↓$ ( $\approx$ )	$↑$ ( $\approx$ )	$↑$ ( $\approx$ )	$\approx$ ( $\approx$ )	$↑$ ( $\approx$ )
Strain rate (C)	Diastolic (ED)	$\approx$ ( $\approx$ )	$↑$ ( $↑$ )	$↓$ ( $↑$ )	$\approx$ ( $\approx$ )	$↓$ ( $↓$ )
Strain rate (R)	Systolic (ES)	$↑$ ( $\approx$ )	$↓$ ( $\approx$ )	$↓$ ( $\approx$ )	$\approx$ ( $\approx$ )	$↓$ ( $\approx$ )
Strain rate (R)	Diastolic (ED)	$\approx$ ( $\approx$ )	$↑$ ( $↓$ )	$↑$ ( $↓$ )	$\approx$ ( $\approx$ )	$↑$ ( $↓$ )
Velocity (L,C,R)	Systolic (ES)	$↑$ ( $\approx$ )	$↓$ ( $\approx$ )	$↓$ ( $↓$ )	$\approx$ ( $\approx$ )	$↓$ ( $\approx$ )
Velocity (L,C,R)	Diastolic (ED)	$\approx$ ( $↑$ )	$↑$ ( $↓$ )	$↓$ ( $\approx$ )	$\approx$ ( $\approx$ )	$↓$ ( $↓$ )
LA strain (L)	ES	$\approx$	$↓$	$↓$	$\approx$	$↓$