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. 2021 Jul 21;21:392. doi: 10.1186/s12935-021-02097-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Effects of FER1L4 on cell apoptosis, cell cycle, cell migration, and invasion. A, B Flow cytometric analysis in apoptotic rate and cell cycle arrest of K-1 and TPC-1 cells transfected with siRNA targeting FER1L4. C Expression level of apoptotic markers and cell cycle S phase checkpoint proteins in PTC cells after depletion of FER1L4. D–F Tumor growth in mice subcutaneously implanted with FER1L4 silenced TPC-1 cells, and the tumor images, growth curves and weight were shown (n = 5). G Representative images of immunohistochemistry staining of Ki67 in implanted tumor sections. Scale bars = 100 μm. H Effects of silencing FER1L4 on cellular migration by wound healing assay. I, J Transwell assays were conducted to investigate the influence of silencing FER1L4 or overexpression of FER1L4 on cellular migration and invasion. Scale bars = 100 μm. Error bars, mean ± SD. * P < 0.05; ** P < 0.01; *** P < 0.001