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. 2021 Jul 21;21:392. doi: 10.1186/s12935-021-02097-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — CDH4 promoted PTC cell proliferation and invasion. A Implanted tumors in mice were harvested and photographed. B The final tumor weight of implanted tumors was calculated. C Immunohistochemistry analysis of CDH4 in PTC tissues and adjacent normal tissues. D, E Knockdown of CDH4 inhibited PTC cell migration and invasion as suggested by wound healing assays and transwell assays. Scale bars = 100 μm. F Detection of CDH4 protein level in TPC-1 cells co-transfected with miR-612 inhibitor and CDH4 siRNA. (G) Cellular growth curves of PTC cells co-transfected with miR-612 inhibitor and CDH4 siRNA determined by CCK8 assays. H, I Rescue effects of miR-612 inhibitor on CDH4 siRNA-mediated inhibition of cellular migration and invasion. Error bars, mean ± SD. * P < 0.05; ** P < 0.01; *** P < 0.001