Table 1.
Clinical characteristics and outcome of patients
| Patient | Age (years) | Symptoms | Etiology of AS (times) | Prior repair attempts | Score of AS at 1st HSA | Previous treatment received | ET (pre-/post-therapy mm) | Pregnancy outcome |
|---|---|---|---|---|---|---|---|---|
| P1 | 39 |
Infertility (3 years) Hypomenorrhea |
5 D&C | 3 HSA | AS Stage II | Estrogen/Aspirin/Heparin/GH/Sildenafil/traditional Chinese medicine | 5.5/7.1 | 2 FET and implantation failure |
| P2 | 33 |
Infertility (3 years) Hypomenorrhea |
1 D&C | 3 HSA | AS Stage III | Estrogen/Aspirin/Heparin/Sildenafil | 3/6.1 | 1 FET and implantation failure |
| P3 | 30 |
Infertility (4 years) Hypomenorrhea |
1 HSP 1 D&C |
5 HSA | AS Stage IV | Estrogen/Aspirin/Heparin/GH /Sildenafil/G-CSF/GM-CSF/traditional Chinese medicine | 5.1/6.6 | 3 FET and implantation failure |
| P4 | 37 | Infertility (3 years) | 6 D&C | 2 HSA | AS Stage IV | Estrogen/Aspirin/Heparin/GH /G-CSF | 5.1/5.9 | 1 FET and implantation failure |
| P5 | 34 |
Infertility (3 years) Hypomenorrhea |
2 D&C | 2 HSA | AS Stage II | Estrogen/Aspirin/traditional Chinese medicine | 5.2/5.8 | 1 FET 4 months post-treatment and cesarean section at 35 + 5 weeks, girl,1950 g |
| P6 | 34 |
Infertility (6 years) Hypomenorrhea |
2 D&C | 5 HSA | AS Stage IV | Estrogen/Aspirin/Heparin/GH/Sildenafil | 2.3/6.1 | 1 FET and implantation failure |
| P7 | 35 |
Infertility (4 years) Hypomenorrhea |
4 D&C | 4 HSA | AS Stage II | Estrogen/Aspirin/Heparin/GH/G-CSF | 5.1/6.4 | 2 FET and implantation failure |
| P8 | 35 |
Infertility (4 years) Hypomenorrhea |
1 D&C | 3 HSA | AS Stage III | Estrogen/Aspirin/Heparin | 4.5/6.6 | 1 FET 2 months post-treatment and abortion at 25+ weeks |
| P9 | 39 |
Infertility (6 years) Hypomenorrhea |
1 D&C | 3 HSA | AS Stage IV | Estrogen/Aspirin/Heparin/GH/Sildenafil | 3.7/5 | 2 FET and implantation failure |
| P10 | 30 |
Infertility (1 year) Hypomenorrhea |
4 D&C | 2 HSA | AS Stage III | Estrogen/Aspirin/Heparin/Sildenafil | 3.5/4.5 | Spontaneous pregnancy 9 months post-treatment and natural labor at 39 weeks, boy, 2600 g |
| P11 | 37 |
Infertility (3 years) Hypomenorrhea |
3 D&C | 2 HSA | AS Stage IV | Estrogen/Aspirin/Heparin | 4.5/- | Did not measure ET after treatment and no FET |
| P12 | 36 |
Infertility (4 years) Hypomenorrhea |
3 D&C | 3 HSA | AS Stage III | Estrogen/Aspirin | 3.4/5.8 | 1 FET and implantation failure |
| P13 | 31 |
Infertility (5 years) Hypomenorrhea |
2 D&C | 3 HSA | AS Stage IV | Estrogen/Aspirin/Heparin/Sildenafil/G-CSF | 4.9/6.4 | 2 FET and implantation failure |
| P14 | 33 |
Infertility (5 years) Hypomenorrhea |
8 D&C | 4 HSA | AS Stage III | Estrogen/Aspirin/Heparin/Sildenafil | 4.2/5.9 | 2 FET and implantation failure |
| P15 | 26 |
Infertility (5 years) Amenorrhea |
2 D&C | 5 HSA | AS Stage VA | Estrogen/Aspirin/Heparin/Sildenafil | 2.5/4.7 | 1 FET and implantation failure |
| P16 | 37 |
Infertility (2 years) Hypomenorrhea |
1 D&C | 3 HSA | AS Stage IV | Estrogen/Aspirin/Heparin | 3.5/- | Withdrew |
| P17 | 32 |
Infertility (1 years) Amenorrhea |
1 D&C | 3 HSA | AS Stage Va | Estrogen/Aspirin/Heparin | 4.4/6.3 | 1 FET 3 months post-treatment and natural labor at 40 + 1 weeks, girl, 2900 g |
| P18 | 39 | Infertility (12 years) | 1 D&C | 3 HSA | AS Stage IV | Estrogen/Aspirin/Heparin/G-CSF | 3/4.7 | 1 FET and implantation failure |
P, patient; D&C, dilatation and curettage; HSP, hysteroscopic polypectomy; HSA, hysteroscopic adhesiolysis; AS, Asherman, syndrome; ET, endometrial thickness; GH, growth hormone; G-CSF, granulocyte colony-stimulating factor; FET, frozen–thawed embryo transfer