TABLE 2.

Terms of the KEGG signal pathway and GO biology function in “focal adhesion” and “response to hormone” clusters based on the analysis of the global signal transduction network.

cluster	Terms	Description	lgP	Genes
Focal adhesion	mmu04510	Focal adhesion	−7.87302	Ptk2, Grb2, Lama2, pdgfra, vwf, parva, flnc
	mmu05231	Choline metabolism in cancer	−4.87407	Grb2, pdgfra, Lypla1, Pld1
	mmu04151	PI3K–Akt signaling pathway	−3.84789	Ptk2, Grb2, Lama2, pdgfra, vwf
	mmu04014	Ras signaling pathway	−3.46729	Grb2, afdn, pdgfra, Pld1
	mmu04072	Phospholipase D signaling pathway	−2.87998	Grb2, pdgfra, Pld1
	mmu05205	Proteoglycans in cancer	−2.46327	Ptk2, Grb2, flnc
	GO:0061138	Morphogenesis of a branching epithelium	−2.356	Grb2, pdgfra, Yap1
	GO:0030029	Actin filament-based process	−2.28504	Grb2, pdgfra, parva, flnc, Tpm4
	GO:0001763	Morphogenesis of a branching structure	−2.2483	Grb2, pdgfra, Yap1
	mmu04010	MAPK signaling pathway	−2.21937	Grb2, pdgfra, flnc
Response to hormone	GO:0009725	Response to hormone	−4.15411	Aldh3a1, Ptk2, Grb2, Pld1, sord, Yap1, Lpin2
	mmu05222	Small cell lung cancer	−3.60391	Ptk2, Lama2, nfkbia
	mmu05200	Pathways in cancer	−3.5909	Ptk2, Grb2, Lama2, nfkbia, pdgfra
	GO:1901652	Response to peptide	−3.57565	Ptk2, Grb2, nfkbia, Pld1, Lpin2
	mmu05215	Prostate cancer	−3.54359	Grb2, nfkbia, pdgfra
	GO:0043434	Response to peptide hormone	−2.85245	Ptk2, Grb2, Pld1, Lpin2
	mmu04062	Chemokine signaling pathway	−2.54939	Ptk2, Grb2, nfkbia
	GO:0071375	Cellular response to peptide hormone stimulus	−2.23374	Ptk2, Grb2, Lpin2
	GO:0032870	Cellular response to hormone stimulus	−2.11301	Ptk2, Grb2, Yap1, Lpin2
	GO:1901653	Cellular response to peptide	−2.03188	Ptk2, Grb2, Lpin2
	GO:0071417	Cellular response to organonitrogen compound	−2.00286	Ptk2, Grb2, pdgfra, Lpin2