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. 2021 Jul 22;21:846. doi: 10.1186/s12885-021-08529-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The abundance of monocyte-derived cells relative to total immune cells is positively associated with the CAPRA-S risk score and negatively associated with disease-free survival. Association of monocyte-derived cell abundance (see Materials and Methods) with disease-free survival in the independent primary prostate cancer TCGA dataset (n = 134). A Polar plot of differential tissue composition of primary prostate cancer TCGA samples for which CAPRA-S risk score information is available, with the factor of interest being CAPRA-S risk score. The y-axis (scaled by the fourth root) represents the overall cell type abundance; the colour coding reflects the association between cell type abundance and disease-free survival (coloured = significant association). B Kaplan–Meier plot of patients (n = 134) with low (blue) or high (red) monocyte-derived cell infiltration in the tumour specimen (proportion cut-off = 0.0048; see Materials and Methods section, Survival analyses subsection). C Kaplan–Meier plot for the other cell types included in the analysis