Table 1.

Summary statistics of the differential transcription analysis, including 52 samples from 13 patients and 4 enriched cell types

Cell type	Total genes	Genes filtered (zeros)	Genes filtered (PPC)	Differentially transcribed			Differentially transcribed in the interface (curated annotation)
				Total (up/down)	Of which cancer genes	Of which PC genes	Total (up/down)	Of which cancer genes, consistent	Of which PC genes, consistent
Epithelial	21,618	5408	189	171 (139/32)	45 (26%)	29 (64%)	80 (67/13)	35 (44%)	23 (67%)
Fibroblast	21,510	7141	651	267 (156/111)	27 (10%)	9 (33%)	97 (58/39)	17 (18%)	7 (41%)
Myeloid	22,507	13,836	2695	900 (827/73)	56 (6%)	11 (20%)	261 (238/23)	32 (12%)	10 (31%)
T cell	21,716	8807	540	288 (195/93)	42 (15%)	18 (42%)	83 (55/28)	26 (31%)	15 (58%)

PPC posterior predictive check, PC prostate cancer. “Of which” refers to the gene selection relative to the category adjacent on the left. “Interface” refers to cell-surface and secreted protein-coding genes. “Curated” refers to the curated database for cellular-interface genes produced in our study (Supplementary file 2). “Consistent” refers to a consistent direction of transcriptional change according to the curated database. Genes were labelled as “cancer genes” if present in the tier1 COSMIC databasehttps://paperpile.com/c/BQQ95X/zLPNs [46] or labelled as such in our manually curated cell-type-specific database (Supplementary file 2). Genes were labelled as “prostate cancer genes” if present in the tier1 COSMIC prostate cancer database datasethttps://paperpile.com/c/BQQ95X/zLPNs [46] or labelled as such in our manually curated cell-type-specific database (Supplementary file 2)