Fig. 6.

Volcano plots of differentially expressed miRNA in wt and mdx mice. The analysis was performed for Naive mdx vs Naive wild type (wt) (A) and Givinostat 37.5 mg/kg vs vehicle (B) contrasts after 15 weeks of treatment (T16). Log2 fold-changes estimated by DESeq2 versus –log10 adjusted p values (FDR: false discovery rate) are indicated in the plot. Black dots indicate miRNA with non-significant fold change (FDR > 0.05). Pink dots indicate significantly differentially expressed miRNAs at FDR < 0.05