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. 2021 Jul 22;12:413. doi: 10.1186/s13287-021-02480-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Hypoxic preconditioning attenuates cellular senescence of OM-MSCs by upregulating miR-326 in vitro model. A Expression of miR-326 in OM-MSCs after transfection of mimics and inhibitors. B Under the hemin treatment, western blotting and quantitative analysis of the expression levels of p21, P53, and p16INK4A in normoxia OM-MSCs transfected with miRNA mimics control or miR-326 mimics. C Representative images of SA-β-gal staining and quantitative analysis of SA-β-gal-positive normoxia OM-MSCs transfected with miRNA mimics control or miR-326 mimics. D Representative images of SA-β-gal staining and quantitative analysis of SA-β-gal-positive hypoxia OM-MSCs transfected with miRNA inhibitor control or miR-326 inhibitor. E Western blotting and quantitative analysis of the expression levels of p21, P53, and p16INK4A in hypoxia OM-MSCs transfected with miRNA inhibitor control or miR-326 inhibitor. Data are expressed as the mean ± SEM (n = 3) (^*P <0.05, ^**P <0.01, ^***P <0.001)