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. 2021 Jul 22;12:413. doi: 10.1186/s13287-021-02480-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — miR-326 attenuates cellular senescence of hypoxia OM-MSCs by promoting autophagy in vitro model. A Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses of miR-326. B Western blotting and quantitative analysis of the expression levels of LC3II/I, Bcelin-1, and P62 in Hemin-exposed normoxia and hypoxia OM-MSCs. C Western blotting and quantitative analysis of the expression levels of LC3II/I, Bcelin-1, and P62 in normoxia OM-MSCs transfected with miRNA mimics control or miR-326 mimics. D Western blotting and quantitative analysis of the expression levels of LC3II/I, Bcelin-1, and P62 in hypoxia OM-MSCs transfected with miRNA inhibitor control or miR-326 inhibitor. E Western blotting analysis of LC3II/I, Bcelin-1, P62, p21, P53, and p16INK4A protein expression in normoxia MSCs transfected with miRNA mimics control, or miR-326 mimics, or miR-326 mimics +3MA. F Western blotting analysis of LC3II/I, Bcelin-1, P62, p21, P53, and p16INK4A protein expression in hypoxia MSCs transfected with miRNA inhibitor control, or miR-326 inhibitor, or miR-326 inhibitor + rapamycin. Data are expressed as the mean ± SEM (n = 3) (^*P <0.05, ^**P <0.01, ^***P <0.001)