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. 2021 Jul 22;11:142. doi: 10.1186/s13578-021-00650-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Recruiting recycling endosomes, abluminal SNAREs, and Caveolin-independent pathway by transcytosis-depending of Br-EVs through BBB. a Flow cytometry analysis of BBB crossing of Br-conjugated EVs under the administration of different inhibitors of endocytosis pathway compared to the control groups. b Fluorescence images exhibiting TdTom-Br-EVs co-localization with dextran and Alexa transferrin, markers of micropinocytosis and clathrin-dependent endocytosis, subsequently. The co-localization of Br-EVs with Rab11 (c) DQ-Ovalbumin (d) Co-localization of Rab11 and DQ-Ovalbumin positive Br-EVs (e) VAMP3 (f) VAMP7 (g) Co-localization of VAMP-3 and VAMP7 positive Be-EVs (h) Syntaxin (i) and Snap3 (j). The white arrows represent co-localization

(Adapted with permission [72]. Copyright 2019, ACS Nano)