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. 2021 Jul 22;11:142. doi: 10.1186/s13578-021-00650-0

Fig. 8.

Fig. 8

Biological fate and direction of endosomal traffic of exosomes. Endocytic exosomes by receptor-mediated transcytosis could direct to the endo-lysosomal pathway and be degraded by lysosomes inside endothelial cells. Pericytes, astrocytes, microglia, and oligodendrocytes can uptake the exosomes in the abluminal side of the brain. The distribution of exosomes could not be specific to the injured site after crossing BBB. In the context of neurodegenerative diseases, the delivered exosomes may migrate to remote areas