Table 1.

2-Sample MR, decreasing lung function effect on cognitive function

Lung function measure	No. of SNPs	Test used	Cognitive function
			Beta (SE)	p-value	Q_P-value
FEV1, FVC, FEV1/FVC, PEF	173	IVW	− 0.002 (0.02)	0.86	1.44 × 1011
		Weighted median	0.02 (0.02)	0.44
		Weighted Mode	− 0.004 (0.03)	0.91
		MR Egger	− 0.005 (0.03)	0.90
FEV1	59	IVW	− 0.05 (0.04)	0.44	1.8 × 10–8
		Weighted median	− 0.02 (0.04)	0.46
		Weighted mode	− 0.05 (0.08)	0.51
		MR Egger	− 0.09 (0.1)	0.43
FVC	68	IVW	− 0.004 (0.03)	0.87	0.01
		Weighted median	− 0.02 (0.04)	0.51
		Weighted mode	− 0.03 (0.07)	0.65
		MR Egger	− 0.16 (0.10)	0.13
FEV1/FVC	93	IVW	0.01 (0.02)	0.52	0.01
		Weighted median	0.02 (0.02)	0.52
		Weighted mode	0.007 (0.05)	0.87
		MR Egger	0.02 (0.04)	0.67

Negative beta indicates decreasing cognitive function

SE, standard error; Q_P-value, a measure of heterogeneity (p-value < 0.05 provides strong evidence of heterogeneity)