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. 2021 Jul 22;19:316. doi: 10.1186/s12967-021-02981-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — The total m6A level and qRT-PCR validation of the m6A-related feature genes in patients with MS. a The total m6A RNA methylation context of total RNA between PMS patients and RRMS patients (PMS vs. RRMS = 0.515 ± 0.154% vs. 1.488 ± 0.611%, p = 0.036). b–i The gene expression of the feature genes ALKBH5, HNRNPC, KIAA1429, METTL3, WTAP, YTHDF1, YTHDF2, and YTHDC2 between PMS patients and RRMS patients (ALKBH5: PMS vs. RRMS = 1.004 ± 0.091 vs. 1.702 ± 0.110, p = 0.002; HNRNPC: PMS vs. RRMS = 1.002 ± 0.070 vs. 1.549 ± 0.262, p = 0.046; KIAA1429: PMS vs. RRMS = 1.003 ± 0.068 vs. 1.760 ± 0.242, p = 0.013; METTL3: PMS vs. RRMS = 1.015 ± 0.178 vs. 1.680 ± 0.202, p = 0.025; WTAP: PMS vs. RRMS = 1.002 ± 0.072 vs. 1.399 ± 0.123, p = 0.017; YTHDF1: PMS vs. RRMS = 1.003 ± 0.083 vs. 2.432 ± 0.407, p = 0.008; YTHDF2: PMS vs. RRMS = 1.012 ± 0.153 vs. 1.364 ± 0.057, p = 0.038; YTHDC2: PMS vs. RRMS = 1.078 ± 0.372 vs. 1.478 ± 0.180, p = 0.243). j–q The gene expression of the feature genes ALKBH5, HNRNPC, KIAA1429, METTL3, WTAP, YTHDF1, YTHDF2, and YTHDC2 between PMS patients and non-MS patients (ALKBH5: PMS vs. non-MS = 1.000 ± 0.026 vs. 1.034 ± 0.030, p = 0.295; HNRNPC: PMS vs. non-MS = 1.075 ± 0.429 vs. 0.830 ± 0.024, p = 0.465; KIAA1429: PMS vs. non-MS = 1.000 ± 0.025 vs. 1.085 ± 0.048, p = 0.092; METTL3: PMS vs. non-MS = 1.000 ± 0.024 vs. 0.920 ± 0.034, p = 0.005; WTAP: PMS vs. non-MS = 1.052 ± 0.351 vs. 0.866 ± 0.010, p = 0.495; YTHDC2: PMS vs. non-MS = 1.051 ± 0.301 vs. 0.753 ± 0.149, p = 0.277; YTHDF1: PMS vs. non-MS = 1.000 ± 0.007 vs. 0.972 ± 0.047, p = 0.457; YTHDF2: PMS vs. non-MS = 1.000 ± 0.006 vs. 0.973 ± 0.135, p = 0.790). The significant levels were set at p < 0.05 (*), < 0.01 (**), and < 0.001 (***)