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. 2021 Jul 21;9(7):e003079. doi: 10.1136/jitc-2021-003079

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Progression-free survival (PFS) of anti-PD-1 antibody-treated patients stratified by changes in ¹⁸F-FLT PET parameters. Kaplan–Meier curves of PFS stratified by changes between baseline and week 2 (n=25, ΔSUV_max0-2 (A), ΔPTV0-2 (B), ΔTLP0-2 (C)), and changes between baseline and week 6 (n=22, ΔSUV_max0-6 (D), ΔPTV0-6 (E), ΔTLP0-6 (F)) with cut-off values as determined by ROC curve analysis. ¹⁸F-FLT, 3′-deoxy-3′-[¹⁸F ]-fluorothymidine; PET, positron emission tomography; PTV, proliferative tumor volume; ROC, receiver operating characteristic; SUV, standardized uptake value; TLP, total lesion proliferation.